The effects of magnetic stimulation on nerve cell apoptosis and the expression of B cell lymphoma/leukemia gene 2 and the caspase 3 gene after spinal cord injury / 中华物理医学与康复杂志

Objective To study the effect of magnetic stimulation on the expression of B cell lymphoma/leukemia gene 2 ( Bcl-2 ) and caspase-3 genes, and the apoptosis of neurons in rats with spinal cord injury (SCI).Methods Sixty rats were randomly divided into a magnetic stimulation group, a model group and a sham-operation group. An SCI model was established in the magnetic stimulation and model groups. The magnetic stimulation was applied at the 6th, 12th, 24th and 72nd hour after the operation to the rats in the magnetic stimulation group, and sham magnetic stimulation was given to the model group and sham-operation group rats at the same time points. Two hours after treatment, 5 rats of each group were sacrificed and their injured spinal cords were sectioned. The gene expressions were detected using immunohistochemical techniques, and apoptosis of neurons was observed by the TUNEL method. Results Few apoptotic cells were found in the sham-operation group, but more were found in the model group. Apoptotic cells in the magnetic stimulation group were significantly fewer than in the model group. The expression of both Bcl-2 and caspase-3 in the magnetic stimulation and model groups was significantly higher than in the sham-operation group at the different time points. Expression of Bcl-2 in the magnetic stimulation group was significantly higher than in the model group, but expression of caspase-3 in the magnetic stimulation group was significantly lower than in the model group. Conclusions Magnetic stimulation up-regulates the expression of Bcl-2 genes and down-regulates the expression of caspase-3 in injured neurons. Magnetic stimulation might have protective and rehabilitative effects after human SCI.

Effect of Hyperuricemia on Recovery of Motor Function and Activities of Daily Living after Cerebral Infarction / 中国康复理论与实践

@#ObjectiveTo investigate the effects of hyperuricemia on motor function, activities of daily living (ADL) in patients with cerebral infarction. Methods120 patients with cerebral infarction were divided into control group (n=60) and hyperuricemia group (n=60). Two groups accepted the similar training of equal time and intensity, and were assessed with Fugl-Meyer Assessment (FMA) and Modified Barthel Index (MBI). ResultsAfter 4 weeks training, the increase of score of FMA and MBI in the hyperuricemia group was obviously lower than in the control group (P＜0.01). ConclusionHyperuricemia could adversely affect the discovery of motor function and ADL in patients with cerebral infarction who accepted rehabilitation.